Hematopoietic Cell Transplantation in Japan
Annual Report of Nationwide Survey 2022 Summary Slide

This slide presents the results of data compilation and basic analyses of the unified and electronic information collected from registered recipients and donors for hematopoietic stem cell transplantation using the Transplant Registry Unified Management Program (TRUMP).

When the contents of this slide are cited or reproduced, the information source must be indicated as described below^*; provided, however, that any modification of the contents (data compilation and analysis results) is prohibited. Please contact us in advance whenever you have questions.

* "Hematopoietic Cell Transplantation in Japan Annual Report of Nationwide Survey 2022 Summary Slide provided by the Japanese Data Center for Hematopoietic Cell Transplantation (JDCHCT)"

Hematopoietic Cell Transplantation in Japan Annual Report of Nationwide Survey 2022 Summary Slide
Appendix to slide34-84: The number of patients in each group and crude survival probabilities

• Slides 3 to 25 show graphs indicating the number of transplants (by disease type, age group, etc.).
• Slides 26 to 33 show graphs indicating year-to-year changes in survival rates 100 and 365 days after first transplantation.
• Slides 34 to 84 show survival curves (by transplant type, disease type, age group, etc.), together with tables showing the number of patients in each group and crude survival rates 1, 5, and 10 years after first transplantation.
• The survival outcomes shown in Slides 26 to 84 are not adjusted for background characteristics or other influential factors and are rough survival outcomes. Accordingly, the survival outcomes are not compared with each other. Special attention should be paid to interpretation of survival outcomes.

• Classification of the intensity of pre-transplant conditioning regimen is based on drug type as well as dose amount and dosing schedule, with several patterns for classification. This graph shows results of data compilation using the definitions of classification reported in, "Giralt et al. Reduced-intensity conditioning regimen workshop: defining the dose spectrum. Report of a workshop convened by the center for international blood and marrow transplant research. Biol Blood Marrow Transplant. 2009 Mar;15(3):367-9."
  • Myeloablative conditioning is defined as therapy with a total body irradiation dose >8 Gy, melphalan dose >140 mg/m2, or busulfan ≥9 mg/kg. When no information regarding irradiation or drug doses is available, making classification according to the above-described definitions impossible, the attending physician determines whether or not the pre-transplant conditioning was myeloablative or nonmyeloablative.
• Risk groups for leukemia are classified using the definitions described below.
  • Standard Risk Group : acute myelogenous leukemia (first complete remission／second complete remission), acute lymphoblastic leukemia (first complete remission), chronic myelogenous leukemia (complete hematologic response／first chronic phase), and myelodysplastic syndrome (WHO 2017 classification： MDS with single lineage dysplasia／MDS-RS and single lineage dysplasia／MDS-RS and multilineage dysplasia／MDS with multilineage dysplasia／MDS with isolated del(5q)／MDS, unclassifiable／Refractory cytopenia of childhood (provisional entity)
    WHO old classification, FAB classification：refractory anemia[RA] ／refractory anemia with ring sideroblasts[RARS]／refractory cytopenia with multilineage dysplasia[RCMD]／refractory cytopenia with multilineage dysplasia and ringed sideroblasts[RCMD-RS]／myelodysplastic syndrome associated with isolated del（5q）chromosome abnormality[5q−syndrome])
  • Advanced risk group: all conditions other than those listed above